An In Vitro Study of Correlation Between the Compositions, Structure and Mechanical Properties of the Arterial Plaque

Atherosclerosis developed in the arterial wall is major cause of cardiovascular events such as stroke and heart failure. Atherosclerosis, also referred to plaque can be classified stable, unstable, vulnerable plaque. In terms features compositions structures, atherosclerosis calcified plaque, with a lipid core, thin fibrous cap. It expected that compositions, mechanical properties plaques interrelate each other. The correlations between structure, are characterize nature rupture provide important clinical information. To date, comprehensive knowledge about correlation lacking. this project, various artificial different structures were fabricated. Porcine fat extracted when it was exposed sun at 30c0, used represent core specimen, while gelatine from bovine skin collagen human placenta fabricate cap specimen. calcification specimen prepared using calcium chloride hexahydrate collagen. eight types evaluated through unconfined compression test. experimental results demonstrate high percentage thicker tends possess large Youngs Module. There strong positive collagen, thickness cap, Module both A negative found